AimWhite matter changes in individuals at ultra-high risk for psychosis (UHR) may be involved in the transition to psychosis. Sleep-wake disturbances commonly precede the first psychotic episode and predict development of psychosis. We examined associations between white matter microstructure and sleep-wake disturbances in UHR individuals compared to healthy controls (HC), as well as explored the confounding effect of medication, substance use, and level of psychopathology.MethodsSixty-four UHR individuals and 35 HC underwent clinical interviews and diffusion weighted imaging. Group differences on global (...) and callosal mean fractional anisotropy (FA) was tested using general linear modeling. Sleep-wake disturbances were evaluated using the subjective measures disturbed sleep index (DSI) and disturbed awakening index (AWI) from the Karolinska Sleep Questionnaire, supported by objective sleep measures from one-night actigraphy. The primary analyses comprised partial correlation analyses between global FA/callosal FA and sleep-wake measures. Secondary analyses investigated multivariate patterns of covariance between measures of sleep-wake disturbances and FA in 48 white matter regions of interest using partial least square correlations.ResultsUltra-high risk for psychosis individuals displayed lower global FA (F = 14.56, p < 0.001) and lower callosal FA (F = 11.34, p = 0.001) compared to HC. Subjective sleep-wake disturbances were significantly higher among the UHR individuals (DSI: F = 27.59, p < 0.001, AWI: F = 36.42, p < 0.001). Lower callosal FA was correlated with increased wake after sleep onset (r = −0.34, p = 0.011) and increased sleep fragmentation index (r = −0.31, p = 0.019) in UHR individuals. Multivariate analyses identified a pattern of covariance in regional FA which were associated with DSI and AWI in UHR individuals (p = 0.028), but not in HC. Substance use, sleep medication and antipsychotic medication did not significantly confound these associations. The association with objective sleep-wake measures was sustained when controlling for level of depressive and UHR symptoms, but symptom level confounded the covariation between FA and subjective sleep-wake measures in the multivariate analyses.ConclusionCompromised callosal microstructure in UHR individuals was related to objectively observed disruptions in sleep-wake functioning. Lower FA in ventrally located regions was associated with subjectively measured sleep-wake disturbances and was partly explained by psychopathology. These findings call for further investigation of sleep disturbances as a potential treatment target. (shrink)

Morderen: menneske.--Metafysik.--Kan naturen tænke?--Menneskets aktivering.--Har filosofien nogen værdi for mennesket?--Samfundenes opløsning.--Sandhed versus løgn.--Det naturlige menneske.--Humanismens elendighed.--Conatus.--Staten.--Spinozas cirkel.--Tog Friedrich Nietzsche fejl?--Børn.--Dåbsattesten.

Large-scale transnational land acquisition of agricultural land in the global south by rich corporations or countries raises challenging normative questions. In this article, the author critically examines and advocates a human rights approach to these questions. Mutually reinforcing, policies, governance and practice promote equitable and secure land tenure that in turn, strengthens other human rights, such as to employment, livelihood and food. Human rights therefore provide standards for evaluating processes and outcomes of transnational land acquisitions and, thus, for determining whether (...) they are ethically unacceptable land grabs. A variety of recent policy initiatives on the issue have evoked human rights, most centrally through the consultation and negotiation of the Voluntary Guidelines on the Responsible Governance of Tenure of Land, Fisheries and Forests concluded in 2012. However, a case of transnational land appropriation illustrates weak host and investor state enforcement of human rights, leaving the parties to in interaction with local groups in charge of protecting human rights. Generally, we have so far seen limited direct application of human rights by states in their governance of transnational land acquisition. Normative responses to transnational land acquisition—codes of conduct, principles of responsible agricultural investment or voluntary guidelines—do not in themselves secure necessary action and change. Applying human rights approaches one must therefore also analyze the material conditions, power relations and political processes that determine whether and how women and men can secure the human rights accountability of the corporations and governments that promote large-scale, transnational land acquisition in the global south. (shrink)

Bridging the gap between the world of science and the realm of the spiritual, B. Alan Wallace introduces a natural theory of human consciousness that has its roots in contemporary physics and Buddhism. Wallace's "special theory of ontological relativity" suggests that mental phenomena are _conditioned_ by the brain, but do not _emerge_ from it. Rather, the entire natural world of mind and matter, subjects and objects, arises from a unitary dimension of reality that is more fundamental than these dualities, as (...) proposed by Wolfgang Pauli and Carl Jung. To test his hypothesis, Wallace employs the Buddhist meditative practice of _samatha_, refining one's attention and metacognition, to create a kind of telescope to examine the space of the mind. Drawing on the work of the physicist John Wheeler, he then proposes a more general theory in which the participatory nature of reality is envisioned as a self-excited circuit. In comparing these ideas to the Buddhist theory known as the Middle Way philosophy, Wallace explores further aspects of his "general theory of ontological relativity," which can be investigated by means of _vipasyana_, or insight, meditation. Wallace then focuses on the theme of symmetry in reference to quantum cosmology and the "problem of frozen time," relating these issues to the theory and practices of the Great Perfection school of Tibetan Buddhism. He concludes with a discussion of the general theme of complementarity as it relates to science and religion. The theories of relativity and quantum mechanics were major achievements in the physical sciences, and the theory of evolution has had an equally deep impact on the life sciences. However, rigorous scientific methods do not yet exist to observe mental phenomena, and naturalism has its limits for shedding light on the workings of the mind. A pioneer of modern consciousness research, Wallace offers a practical and revolutionary method for exploring the mind that combines the keenest insights of contemporary physicists and philosophers with the time-honored meditative traditions of Buddhism. (shrink)

Addresses the concept of truth in Chinese Daoist philosophy and ritual. Through wide-ranging research into Daoist ritual, both in history and as it survives in the present day, shows that the concept of true reality that informs this tradition posits being as a paradox anchored in the inexistent Way"--Provided by publisher.

Bridging the gap between the world of science and the realm of the spiritual, B. Alan Wallace introduces a natural theory of human consciousness that has its roots in contemporary physics and Buddhism. Wallace's "special theory of ontological relativity" suggests that mental phenomena are _conditioned_ by the brain, but do not _emerge_ from it. Rather, the entire natural world of mind and matter, subjects and objects, arises from a unitary dimension of reality that is more fundamental than these dualities, as (...) proposed by Wolfgang Pauli and Carl Jung. To test his hypothesis, Wallace employs the Buddhist meditative practice of _samatha_, refining one's attention and metacognition, to create a kind of telescope to examine the space of the mind. Drawing on the work of the physicist John Wheeler, he then proposes a more general theory in which the participatory nature of reality is envisioned as a self-excited circuit. In comparing these ideas to the Buddhist theory known as the Middle Way philosophy, Wallace explores further aspects of his "general theory of ontological relativity," which can be investigated by means of _vipasyana_, or insight, meditation. Wallace then focuses on the theme of symmetry in reference to quantum cosmology and the "problem of frozen time," relating these issues to the theory and practices of the Great Perfection school of Tibetan Buddhism. He concludes with a discussion of the general theme of complementarity as it relates to science and religion. The theories of relativity and quantum mechanics were major achievements in the physical sciences, and the theory of evolution has had an equally deep impact on the life sciences. However, rigorous scientific methods do not yet exist to observe mental phenomena, and naturalism has its limits for shedding light on the workings of the mind. A pioneer of modern consciousness research, Wallace offers a practical and revolutionary method for exploring the mind that combines the keenest insights of contemporary physicists and philosophers with the time-honored meditative traditions of Buddhism. (shrink)

We propose the FoodSmart City framework as a transdisciplinary avenue to promote sustainable seafood consumption. We argue that a change in human seafood consumption towards eating at lower trophic levels may be helped by discovering forgotten cultural practices and tapping into locally-sourced marine resources. We set out a framework of knowledge exchange and production between academia, businesses, and civil society to promote and assist healthy and ecologically sustainable living using digital tools and intangible cultural heritage while engaging with innovative chefs (...) and educationalists. The framework targets Dublin City, Ireland, but may potentially be replicated in other contexts. (shrink)

Disintegration and mechanisation.--Sacrifice and atonement.--Communion and the community.--The life-mass and the death-mass.--Life's clair-obscure.

This paper presents an interpretation of Husserl''s phenomenological epoché or bracketing ( Einklammerung), which makes it possible to compare his position with philosophical programs developed within the framework of modern analytical philosophy. At the same time it asks in what sense Husserl''s phenomenology is a form of idealism or exceeds the traditional discussion of idealism versus realism.

This book is open access under a CC BY license. The first of its kind, this 'Report' gives an overview of the humanities worldwide. Published as an Open Access title and based on an extensive literature review and enlightening interviews conducted with 90 humanities scholars across 40 countries, the book offers a first step in attempting to assess the state of the humanities globally. Its topics include the nature and value of the humanities, the challenge of globalisation, the opportunities offered (...) by the digital humanities, variations in funding patterns around the world, and the interaction between humanities and society. Despite the stereotypical view of humanists as scholars locked away in their ivory towers, the picture that emerges from this report is that they are deeply committed to the social value of their work and appreciate the long-term importance it has for addressing global challenges. The report will be of interest not only to researchers and students in the humanities themselves, but also to administrators and funders. (shrink)

This volume on anthropology and authority in the writings of Søren Kierkegaard (1813-1855) offers its reader nineteen timely discussions of two fundamental categories pertaining to the literary, philosophical, and theological production of this prominent 19th century Danish thinker, whose vast influence upon 20th century intellectual life continues to grow as the new millennium approaches. The volume's nineteen contributors - from Canada, Denmark, Great Britain, Holland, Hungary, Italy, and the United States - inquire into such complex problematics in Kierkegaard's oeuvre as (...) the interrelationship between the human, the divine, and the spiritual; between the secular and the Christian; between human and Christian love; between state and church institutions and the single individual of faith; and between this individual's concern for quality in civic and religious life and the quantitative forces of modern society's masses and crowds. Special attention is given to the indisputable authority of God, Christ, and the apostles as opposed to the debatable authority, or non-authority, of the author. Of particular interest is the nexus between Kierkegaard's existential and religious concerns, on the one hand, and his intricate textual conceptions, multifarious poetic strategies, and various means of pseudonymous and indirect communication, on the other. Between the covers of Anthropology and Authority some chapters seek to refine received knowledge of Kierkegaard in such disciplines as theology and moral philosophy. Conversely, other chapters submit rather postmodern critiques of the author's stylistic and rhetorical devices. A summary assessment of the nineteen contributions would fail to recognize this considerable methodological and theoretical diversity. Instead, the reader's access to the smorgasbord of insights has been facilitated by an introduction in which one of the American editors briefly outline the individual contributions on a general historical and intellectual background. Altogether, the probing insights of Anthropology and Authority go to the core of Søren Kierkegaard's authorship. Individual chapters either update previous responses to the many challenges presented by this work, or the chapters face new challenges and/or present critical challenges on their own. (shrink)

This chapter discusses Kierkegaard's impact on creative writers worldwide. Traditional attempts to identify his individual “influence” have increasingly yielded to an interest in “intertextuality,” a more socially oriented take on authorial interrelationships, overcoming the narrow specificity of “influence,” while sometimes tending to be overly broad and general instead. Concurrently, Kierkegaard's role as a literary writer has recently been favored over his role as a Christian thinker, although by no means exclusively so. Altogether, intertextual reception of his corpus significantly extends his (...) literary profile as an existential storyteller, while also engaging in a multifaceted dialogue about both humanism and anti‐humanism. (shrink)